PT-141 (Bremelanotide)
A melanocortin-pathway peptide for sexual desire — FDA-approved as Vyleesi®.
PT-141 (Bremelanotide) works through the brain’s melanocortin system to enhance sexual arousal — a different mechanism than blood-flow medications like sildenafil. It’s FDA-approved as Vyleesi® for low sexual desire in premenopausal women and used off-label in men.
Prescription required. Final clinical decisions rest with the prescribing physician.
What is PT-141 (Bremelanotide)?
Unlike PDE5 inhibitors (sildenafil, tadalafil) that act on blood flow, PT-141 works centrally — activating melanocortin receptors in the nervous system to influence sexual desire and arousal. This makes it relevant for low libido as well as erectile concerns.
It’s FDA-approved as Vyleesi® for hypoactive sexual desire disorder in premenopausal women and is used off-label in men. Compounded strengths are also available through licensed pharmacies under prescription.
Potential benefits
Targets desire, not just blood flow
Acts through the brain’s melanocortin pathway — distinct from PDE5 inhibitors.
Works for men and women
Used for low libido in both, with an FDA-approved indication in women.
On-demand
Used before activity rather than daily.
Can complement ED meds
Sometimes used alongside sildenafil/tadalafil under physician guidance.
How it works
How it’s taken
A small subcutaneous injection taken on-demand, typically ahead of anticipated activity. The physician sets dosing limits.
Typical protocol
Used as-needed within physician-set frequency limits; not a daily medication.
How ordering works
Complete the intake
Share your goals, health history, and current medications — about 5 minutes.
Physician evaluation
An independent, board-certified physician reviews your intake and, if appropriate, prescribes PT-141 (Bremelanotide) with a dosing protocol.
Compounded & shipped
The prescription is filled by a licensed compounding pharmacy and shipped to your door with instructions.
What to know before PT-141 (Bremelanotide)
PT-141 (Bremelanotide) is a bioactive compound. The physician you’re connected with will review the relevant risks and contraindications for your situation before prescribing.
- •Nausea is the most common side effect; facial flushing can occur.
- •Can transiently raise blood pressure — not suitable for uncontrolled hypertension or significant cardiovascular disease.
- •Disclose blood pressure and cardiovascular history and current medications.
- •Use within physician-set frequency limits; the physician will confirm suitability.
PT-141 (Bremelanotide) FAQ
What is PT-141 used for?
PT-141 is used for low sexual desire and arousal. It’s FDA-approved as Vyleesi® for premenopausal women and used off-label in men.
How is PT-141 different from Viagra?
Sildenafil/tadalafil act on blood flow; PT-141 acts centrally on the brain’s melanocortin pathway to influence desire — a different mechanism.
How is it taken?
A small subcutaneous injection on-demand before activity, within physician-set limits.
Is it safe with blood-pressure issues?
It can transiently raise blood pressure, so it isn’t suitable for uncontrolled hypertension — disclose your cardiovascular history.
How much does it cost?
PT-141 starts from $99/month. Final pricing is confirmed after your physician evaluation. The initial evaluation is free.
Ready to start PT-141 (Bremelanotide)?
Complete a short medical intake — a supervising physician reviews it and, if appropriate, writes your prescription, and a licensed pharmacy ships to your door.
Pricing & regulatory note: The $99/mo price is an indicative starting point confirmed by the compounding pharmacy after physician evaluation. PT-141 (Bremelanotide) is not an FDA-approved finished drug product; it is prepared by licensed compounding pharmacies and prescribed off-label. FDA guidance on peptide compounding continues to evolve and availability can change. A prescription is required.