MOTS-c
A mitochondrial-derived peptide studied for metabolism, energy, and exercise capacity.
MOTS-c is a peptide encoded in mitochondrial DNA, studied as an “exercise-mimetic” for its effects on metabolism, insulin sensitivity, and energy.
Prescription required. Final clinical decisions rest with the prescribing physician.
What is MOTS-c?
MOTS-c is a mitochondrial-derived peptide — encoded in the DNA of the mitochondria themselves. Research interest centers on its role in metabolic regulation, insulin sensitivity, and exercise capacity, leading some to describe it as an “exercise mimetic.”
It is accessed through licensed compounding pharmacies under a physician’s prescription; it is not an FDA-approved finished product, and FDA guidance on peptide compounding continues to evolve.
Potential benefits
Metabolic support
Studied for metabolic regulation and insulin sensitivity.
Energy & exercise capacity
Described as an exercise-mimetic in research.
Mitochondrial health
Acts on mitochondrial signaling pathways.
Body composition
Used in metabolic/longevity protocols.
How it works
How it’s taken
A subcutaneous injection on a cycle set by the prescribing physician.
Typical protocol
Often run in cycles; the physician sets the dose and schedule.
How ordering works
Complete the intake
Share your goals, health history, and current medications — about 5 minutes.
Physician evaluation
An independent, board-certified physician reviews your intake and, if appropriate, prescribes MOTS-c with a dosing protocol.
Compounded & shipped
The prescription is filled by a licensed compounding pharmacy and shipped to your door with instructions.
What to know before MOTS-c
MOTS-c is a bioactive compound. The physician you’re connected with will review the relevant risks and contraindications for your situation before prescribing.
- •Injection-site reactions are the most common side effect.
- •Long-term human data is limited — most evidence is pre-clinical.
- •Disclose your full history and current medications, including diabetes/glucose management.
- •Source matters: gray-market “research only” peptides skip physician oversight and quality testing. FirstCall connects you with a licensed physician and a compounding pharmacy that follows USP standards.
MOTS-c FAQ
What is MOTS-c used for?
MOTS-c is studied for metabolism, insulin sensitivity, and exercise capacity. It’s prescribed off-label under physician supervision and is not FDA-approved.
Is it FDA-approved?
No. It is prepared by licensed compounding pharmacies and prescribed off-label; FDA guidance on peptide compounding is evolving.
How is it taken?
A subcutaneous injection on a cycle; the physician sets your dose and schedule.
Is it a substitute for exercise?
No — it’s studied as a complement, not a replacement, for diet and exercise.
How much does it cost?
MOTS-c starts from $199/month. Final pricing is confirmed after your physician evaluation. The initial evaluation is free.
Ready to start MOTS-c?
Complete a short medical intake — a supervising physician reviews it and, if appropriate, writes your prescription, and a licensed pharmacy ships to your door.
Pricing & regulatory note: The $199/mo price is an indicative starting point confirmed by the compounding pharmacy after physician evaluation. MOTS-c is not an FDA-approved finished drug product; it is prepared by licensed compounding pharmacies and prescribed off-label. FDA guidance on peptide compounding continues to evolve and availability can change. A prescription is required.