Ipamorelin / Sermorelin
A selective secretagogue plus a GHRH analog — complementary GH support in one combined vial.
Ipamorelin / Sermorelin pairs a selective ghrelin-receptor agonist (Ipamorelin) with a GHRH analog (Sermorelin). The combination encourages the body’s own growth-hormone release through two complementary mechanisms.
Prescription required. Final clinical decisions rest with the prescribing physician.
What is Ipamorelin / Sermorelin?
This blend combines Ipamorelin with Sermorelin — a ghrelin-receptor agonist and a GHRH analog. Together they prompt natural, pulsatile GH release while preserving the body’s feedback loops, which clinicians often prefer over direct growth hormone.
It’s used for sleep, recovery, and body composition, particularly in adults with age-related GH decline. The blend is accessed through licensed compounding pharmacies under physician prescription; it is not an FDA-approved finished product.
Potential benefits
Two complementary pathways
Ghrelin-receptor + GHRH stimulation for a fuller, natural GH response.
Natural, pulsatile release
Preserves the body’s own GH feedback rather than replacing it.
Sleep & recovery
Targets deep sleep, recovery, and body composition.
Single combined vial
Both peptides in one formulation, one injection.
How it works
How it’s taken
A single nightly subcutaneous injection of the combined formulation, dosed before bed per physician protocol.
Typical protocol
Run in cycles with periodic reassessment; the physician sets the ratio, dose, and timing.
How ordering works
Complete the intake
Share your goals, health history, and current medications — about 5 minutes.
Physician evaluation
An independent, board-certified physician reviews your intake and, if appropriate, prescribes Ipamorelin / Sermorelin with a dosing protocol.
Compounded & shipped
The prescription is filled by a licensed compounding pharmacy and shipped to your door with instructions.
What to know before Ipamorelin / Sermorelin
Ipamorelin / Sermorelin is a bioactive compound. The physician you’re connected with will review the relevant risks and contraindications for your situation before prescribing.
- •Injection-site reactions are the most common side effect.
- •May cause mild water retention or flushing after dosing.
- •Active cancer or recent malignancy is a contraindication for GH-stimulating peptides.
- •Pregnancy and breastfeeding are contraindications for most peptides.
- •Source matters: gray-market “research only” peptides skip physician oversight and quality testing. FirstCall connects you with a licensed physician and a compounding pharmacy that follows USP standards.
Ipamorelin / Sermorelin FAQ
What is the Ipamorelin / Sermorelin blend for?
It supports the body’s natural growth-hormone release for sleep, recovery, and body composition, prescribed off-label under physician supervision.
Is it FDA-approved?
No. It is prepared by licensed compounding pharmacies and prescribed off-label; it is not an FDA-approved finished drug product.
How is it different from CJC-1295 / Ipamorelin?
Both pair Ipamorelin with a GHRH analog; this blend uses Sermorelin, which some clinicians prefer for its well-established, natural profile. The physician will recommend the best fit.
How is it taken?
One nightly subcutaneous injection of the combined vial; the physician sets your dose and schedule.
How much does it cost?
The Ipamorelin / Sermorelin blend starts from $189/month. Final pricing is confirmed by the compounding pharmacy after your physician evaluation. The initial evaluation is free.
Ready to start Ipamorelin / Sermorelin?
Complete a short medical intake — a supervising physician reviews it and, if appropriate, writes your prescription, and a licensed pharmacy ships to your door.
Pricing & regulatory note: The $189/mo price is an indicative starting point confirmed by the compounding pharmacy after physician evaluation. Ipamorelin / Sermorelin is not an FDA-approved finished drug product; it is prepared by licensed compounding pharmacies and prescribed off-label. FDA guidance on peptide compounding continues to evolve and availability can change. A prescription is required.